The imagination will have its limit if you start to think about the nerve pain people have and the absolutely horrifying stories of theirs. Take for example diabetic neuropathy which is peripheral in nature. The pain spreads mostly to the lower limbs and makes life annoying, distressing and not to forget extremely painful in its own way. They cannot feel their own feet, as if it is not even there, gone.
The same happened with John, he was diagnosed with Diabetic neuropathy. He returned from a party he had to attend, his wife beside him, he went ahead to park the car but could not apply the brakes, you need legs to apply break, John couldn’t feel his. The car hit the gates, and e could still feel his legs. Such is the horror Neuropathic pain unleashes on its victims. You can’t cover your legs with socks, you can’t put a bed sheet on them, hell you can’t even feel them. Then there are times when it feels like your feet are on fire and then the other moment it feels like its pricking. It disables you says John, the worst few months of his life. He could not enjoy the daily routines, his job was at stake and what not.
The initial pain killers he was given were ineffective and hardly gave him any sense of relief. He switched the doctor and was later given Lyrica 200 mg. John only wishes that he had got this drug earlier.
Lyrica is a well-accepted drug for the treatment of neuropathic pain which generally affects arms, hands, fingers, legs, feet or toes. This medication is a highly potent pain reliever that effectively manages nerve pain in diabetic neuropathy, shingles, herpes zoster, fibromyalgia and spinal cord injury. It is a capsule dosage form that contains Pregabalin as its chief therapeutic ingredient. Lyrica manages pain by suppressing certain chemicals and diminishes the impulses in the brain which is accountable for sending pain signals.
Pregabalin belongs to the anticonvulsants category of drug. It is an analog of GABA (potent inhibitory neurotransmitter). The drug exerts beneficial effects by interacting with alpha2-delta site in the CNS. In addition, it modifies the calcium channel function by decreasing the release of certain calcium dependent neurotransmitters. Pregabalin augments the concentration of GABA by enhancing the availability of an enzyme called GAD. As a result, electric signals from the damaged nerves are suppressed and pain signals do not travel to the brain.
Lyrica is available in dosing strengths of 75mg, 150mg, and 200mg. The dose is best defined by the doctor. While treating diabetic neuropathy, the therapy is usually initiated with 50 mg orally taken 3 times a day which can be further augmented to 100 mg orally taken 3 times a day within one weeks time, keeping in mind the efficacy and tolerability. While treating Post herpetic Neuralgia, the initial dose is 75 mg orally, taken 2 times a day or 50 mg orally 3 times a day, the dose can be further increased to 100 mg orally thrice a day after one week based on efficacy and tolerability.
The most commonly occurring side effects that may bother a few of the users are a drowsiness, confusion, edema, headache, dizziness infection, blurred vision, constipation, fatigue, speech disturbance and increased appetite.
Preventive measures while using Lyrica:
- The use of alcohol or any other recreational drugs with this medication can increase the side effects.
- The elderly are more prone to the side effects of this medicine. They should take it under proper medical guidance.
- Keep a safe distance from driving or doing possibly unsafe tasks as the use of this medication may induce dizziness and drowsiness effects.
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